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Antidepressants And Weight Gain antidepressants cause weight gain How does? Is it just an increase in appetite? I do not eat much at all, and I lost weight for a while. I took an antidepressant a few weeks ago for concern and I am anxious to win back a weight I have lost already. You did not say what the medication was. Antidepressants (TCAs) may make, and the simple explanation I was told at the pharmacy school has been working on their body's thermostat in the hypothalamus to reduce the burning of calories. Lexapro is almost neutral weight gain. Regain of weight that was lost due to anxiety / depression (which may actually be a positive sign of restored health) and / or excessive appetite, probably caused by the blockade of histamine receptors. Posted on February 6, 2010.
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